Williams was taken to the locker room on a cart after he suffered the injury to his right knee in Sunday’s 32-23 loss to the Las Vegas Raiders.
Williams, who entered the game as the Broncos’ leader in carries and rushing yards, stayed down on the field after a 1-yard loss on the first play of the second half.
Mike Boone replaced Williams in the Broncos’ lineup right after Williams went down. Melvin Gordon III had split time with Williams over the first three games of the season, but Gordon fumbled in the second quarter and the Raiders’ Amik Robertson returned it 68 yards for a touchdown.
It was Gordon’s fourth fumble of the season — the Broncos have lost two of them. Gordon did get some carries on the Broncos’ next possession.
Information from ESPN’s Jeff Legwold was used in this report.